西塚研究室

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出版物

The clinical validity of urinary pellet DNA monitoring for the diagnosis of recurrent bladder cancer

Abe M, Hiraki H, Tsuyukubo T, Ono S, Maekawa S, Tamura D, Yashima-Abo A, Kato R, Fujisawa H, Iwaya T, Woong-Yang Park , Idogawa M, Tokino T, Obara W, Nishizuka SS

J Mol Diagn. 2024 Apr;26(4):278-291.　doi: 10.1016/j.jmoldx.2024.01.006

PMID：38301868

Postoperative recurrence detection using individualized circulating tumor DNA in upper tract urothelial carcinoma

Tamura D, Abe M, Hiraki H, Sasaki N, Yashima-Abo A, Ikarashi D, Kato R, Kato Y, Maekawa S, Kanehira M, Takata R, Maejima K, Sasagawa S, Fujita M, Suzuki Y, Nakagawa H, Iwaya T, Nishizuka SS, Obara W.

Cancer Sci. 2024 Feb;115(2):529-539. doi: 10.1111/cas.16025.

PMID：38083992

Immuno-genomic analysis reveals eosinophilic feature and favorable prognosis of female non-smoking esophageal squamous cell carcinomas.

Okawa Y, Sasagawa S, Kato H, Johnson TA, Nagaoka K, Kobayashi Y, Hayashi A, Shibayama T, Maejima K, Tanaka H, Miyano S, Shibahara J, Nishizuka SS, Hirano S, Seto Y, Iwaya T, Kakimi K, Yasuda T, Nakagawa H.

Cancer Lett.2024 Jan 28:581:216499.doi: 10.1016/j.canlet.2023.216499

PMID：38013050

Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses.

Shiraishi K, Takahashi A, Momozawa Y, Daigo Y, Kaneko S, Kawaguchi T, Kunitoh H, Matsumoto S, Horinouchi H, Goto A, Honda T, Shimizu K, Torasawa M, Takayanagi D, Saito M, Saito A, Ohe Y, Watanabe SI, Goto K, Tsuboi M, Tsuchihara K, Takata S, Aoi T, Takano A, Kobayashi M, Miyagi Y, Tanaka K, Suzuki H, Maeda D, Yamaura T, Matsuda M, Shimada Y, Mizuno T, Sakamoto H, Yoshida T, Goto Y, Yoshida T, Yamaji T, Sonobe M, Toyooka S, Yoneda K, Masago K, Tanaka F, Hara M, Fuse N, Nishizuka SS, Motoi N, Sawada N, Nishida Y, Kumada K, Takeuchi K, Tanno K, Yatabe Y, Sunami K, Hishida T, Miyazaki Y, Ito H, Amemiya M, Totsuka H, Nakayama H, Yokose T, Ishigaki K, Nagashima T, Ohtaki Y, Imai K, Takasawa K, Minamiya Y, Kobayashi K, Okubo K, Wakai K, Shimizu A, Yamamoto M, Iwasaki M, Matsuda K, Inazawa J, Shiraishi Y, Nishikawa H, Murakami Y, Kubo M, Matsuda F, Kamatani Y, Hamamoto R, Matsuo K, Kohno T.

Cancer Commun (Lond). 2024 Feb;44(2):287-293. doi: 10.1002/cac2.12498.

 

PMID：37369179

Circulating Cell-Free DNA as a Biomarker for Prognosis and Response to Systemic Therapy in Patients with Unresectable Hepatocellular Carcinoma.

Watanabe T, Suzuki Y, Kuroda H, Hiraki H, Suzuki A, Tamura A, Ieko Y, Nishizuka SS, Matsumoto T.

Oncology. 2023;101(11):714-722.

PMID：37369179

Anti-Helicobacter pylori antibody status isassociated with cancer mortality: A longitudinal analysis from the Japanese DAIKO prospective cohort study

Nishizuka SS, Nakatochi M, Koizumi Y, Hishida A, Okada R, Kawai S, Sutoh Y, Koeda K, Shimizu A, Naito M, Wakai K.

PLOS Glob Public Health. 2023  Feb 8;3(2): e0001125.

PMID：N/A

Proteo-genomic characterization of virus-associated liver cancers reveals potential subtypes and therapeutic targets

Fujita M, Chen MM, Siwak DR, Sasagawa S, Oosawa-Tatsuguchi A, Arihiro K, Ono A, Miura R, Maejima K, Aikata H, Ueno M, Hayami S, Yamaue H, Chayama K, Lee JS, Lu Y, Mills GB, Liang H, Nishizuka SS, Nakagawa H.

Nat Commun. 2022 Oct 29;13(1):6481. doi: 10.1038/s41467-022-34249-x.

PMID：36309506

Helicobacter pylori modulated host immunity in gastric cancer patients with S-1 adjuvant chemotherapy

Koizumi Y, Ahmad S, Ikeda M, Yashima-Abo A, Espina G, Sugimoto R, Sugai T, Iwaya T, Tamura G, Koeda K, Liotta LA, Takahashi F, Nishizuka SS; Northern Japan Gastric Cancer Study Consortium.

J Natl Cancer Inst. 2022 Apr 19:djac085. doi: 10.1093/jnci/djac085. Online ahead of print.

PMID：35437596

Individualized circulating tumor DNA monitoring in head and neck squamous cell carcinoma

Kogo R, Manako T, Iwaya T, Nishizuka S, Hiraki H, Sasaki Y, Idogawa M, Tokino T, Koide A, Komune N, Yasumatsu R, Nakagawa T.

Cancer Med. 2022 Mar 30. doi: 10.1002/cam4.4726. Online ahead of print.

PMID： 35352507

Early dynamics of circulating tumor DNA predict chemotherapy responses for patients with esophageal cancer

Fujisawa R, Iwaya T, Endo F, Idogawa M, Sasaki N, Hiraki H, Tange S, Hirano T, Koizumi Y, Abe M, Takahashi T, Yaegashi M, Akiyama Y, Masuda M, Sasaki A, Takahashi F, Sasaki Y, Tokino T, Nishizuka SS.

Carcinogenesis. 2021 Oct 26;42(10):1239-1249. doi: 10.1093/carcin/bgab088.

PMID：34559206

Editorial Comment to “A nomogram Based on a Collagen Feature Support Vector Machine for Predicting the Treatment Response to Neoadjuvant Chemoradiotherapy in Rectal Cancer Patients”

Yashima-Abo A, Otsuka K, Nishizuka SS.

Ann Surg Oncol. 2021 Oct;28(11):5818-5819. doi: 10.1245/s10434-021-10328-z. Epub 2021 Jun 24.

PMID：34165654

Reply

Iwaya T and Nishizuka SS.

Gastroenterology. 2021 Jul;161(1):367-368. doi:10.1053/j.gastro.2021.03.033. Epub 2021 Mar 22.

PMID：33766565

Frequent post-operative monitoring of colorectal cancer using individualised ctDNA validated by multiregional molecular profiling

Yaegashi M, Iwaya T, Sasaki N, Fujita M, Ju Z, Siwak D, Hachiya T, Sato K, Endo F, Kimura T, Otsuka K, Sugimoto R, Sugai T, Liotta L, Lu Y, Mills GB, Nakagawa H, Nishizuka SS.

Br J Cancer. 2021 Apr;124(9):1556-1565. doi: 10.1038/s41416-021-01266-4. Epub 2021 Mar 3.

PMID：33658639

Frequent Tumor Burden Monitoring of Esophageal Squamous Cell Carcinoma With Circulating Tumor DNA Using Individually Designed Digital Polymerase Chain Reaction

Iwaya T, Endo F, Takahashi F, Tokino T, Sasaki Y, Nishizuka SS.

Gastroenterology. 2021 Jan;160(1):463-465.e4. doi: 10.1053/j.gastro.2020.09.035. Epub 2020 Oct 2.

PMID：33011175

Study Profile of the Tohoku Medical Megabank Community-Based Cohort Study.

Hozawa A, Tanno K, Nakaya N, Nakamura T, Tsuchiya N, Hirata T, Narita A, Kogure M, Nochioka K, Sasaki R, Takanashi N, Otsuka K, Sakata K, Kuriyama S, Kikuya M, Tanabe O, Sugawara J, Suzuki K, Suzuki Y, Kodama EN, Fuse N, Kiyomoto H, Tomita H, Uruno A, Hamanaka Y, Metoki H, Ishikuro M, Obara T, Kobayashi T, Kitatani K, Takai-Igarashi T, Ogishima S, Satoh M, Ohmomo H, Tsuboi A, Egawa S, Ishii T, Ito K, Ito S, Taki Y, Minegishi N, Ishii N, Nagasaki M, Igarashi K, Koshiba S, Shimizu R, Tamiya G, Nakayama K, Motohashi H, Yasuda J, Shimizu A, Hachiya T, Shiwa Y, Tominaga T, Tanaka H, Oyama K, Tanaka R, Kawame H, Fukushima A, Ishigaki Y, Tokutomi T, Osumi N, Kobayashi T, Nagami F, Hashizume H, Arai T, Kawaguchi Y, Higuchi S, Sakaida M, Endo R, Nishizuka S, Tsuji I, Hitomi J, Nakamura M, Ogasawara K, Yaegashi N, Kinoshita K, Kure S, Sakai A, Kobayashi S, Sobue K, Sasaki M, Yamamoto M.

J Epidemiol. 2021 Jan 5;31(1):65-76. doi: 10.2188/jea.JE20190271. Epub 2020 Jan 11.

PMID：31932529

Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer

Lin Y, Nakatochi M, Hosono Y, Ito H, Kamatani Y, Inoko A, Sakamoto H, Kinoshita F, Kobayashi Y, Ishii H, Ozaka M, Sasaki T, Matsuyama M, Sasahira N, Morimoto M, Kobayashi S, Fukushima T, Ueno M, Ohkawa S, Egawa N, Kuruma S, Mori M, Nakao H, Adachi Y, Okuda M, Osaki T, Kamiya S, Wang C, Hara K, Shimizu Y, Miyamoto T, Hayashi Y, Ebi H, Kohmoto T, Imoto I, Kasugai Y, Murakami Y, Akiyama M, Ishigaki K, Matsuda K, Hirata M, Shimada K, Okusaka T, Kawaguchi T, Takahashi M, Watanabe Y, Kuriki K, Kadota A, Okada R, Mikami H, Takezaki T, Suzuki S, Yamaji T, Iwasaki M, Sawada N, Goto A, Kinoshita K, Fuse N, Katsuoka F, Shimizu A, Nishizuka SS, Tanno K, Suzuki K, Okada Y, Horikoshi M, Yamauchi T, Kadowaki T, Yu H, Zhong J, Amundadottir LT, Doki Y, Ishii H, Eguchi H, Bogumil D, Haiman CA, Le Marchand L, Mori M, Risch H, Setiawan VW, Tsugane S, Wakai K, Yoshida T, Matsuda F, Kubo M, Kikuchi S, Matsuo K.

Nat Commun. 2020 Jun 24;11(1):3175. doi: 10.1038/s41467-020-16711-w.

PMID：32581250

Circulating-tumor DNA from Two Types of Blood Collection Tubes for Monitoring Tumor Burden Validated with Esophageal Squamous Cell Carcinoma Patients

Endo F, Iwaya T, Sasaki Y, Chiba T, Yaegashi M, Kume K, Sato K, Arisue A, Kawagishi R, Matuo T, Akiyama Y, Sasaki A, Suzuki Y, Tokino T, Masuda M, Yamada T, Nakagawa H, Nishizuka SS

medRxiv doi: https://doi.org/10.1101/2020.08.12.20173070

PMID：N/A

Analysis of mutational and proteomic heterogeneity of gastric cancer suggests an effective pipeline to monitor post-treatment tumor burden using circulating tumor DNA

Sasaki N, Iwaya T, Chiba T, Fujita M, Ju Z, Endo F, Yaegashi M, Hachiya T, Sugimoto R, Sugai T, Siwak DR, Liotta LA, Lu Y, Mills GB, Nakagawa H, Nishizuka SS.

PLoS One. 2020 Oct 7;15(10):e0239966. doi: 10.1371/journal.pone.0239966. eCollection 2020.

PMID：33027286

Recurrence risk evaluation in T1N1M0/T2N0M0/T3N0M0 gastric cancer with TP53 codon 72 polymorphisms

Ohmori Y, Nomura T, Fukushima N, Takahashi F, Iwaya T, Koeda K, Nishizuka SS; Members of the Northern Japan Gastric Cancer Study Consortium.

J Surg Oncol. 2019 Dec;120(7):1154-1161. doi: 10.1002/jso.25718. Epub 2019 Oct 2.

PMID：31578743

Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population.

Low SK, Chin YM, Ito H, Matsuo K, Tanikawa C, Matsuda K, Saito H, Sakurai-Yageta M, Nakaya N, Shimizu A, Nishizuka SS, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Takezaki T, Suzuki S, Naito M, Wakai K, Kamatani Y, Momozawa Y, Murakami Y, Inazawa J, Nakamura Y, Kubo M, Katagiri T, Miki Y.

Sci Rep. 2019 Nov 22;9(1):17332. doi: 10.1038/s41598-019-53654-9.

PMID：31757997

Affected medical services in Iwate prefecture in the absence of a COVID-19 outbreak

Sasaki N and Nishizuka SS.

medRxiv 2020.06.19.20135269.doi: https://doi.org/10.1101/2020.06.19.20135269

PMID：N/A

RPPAs for cell subpopulation analysis

Kume K and Nishizuka SS.

Adv Exp Med Biol. 2019;1188:227-237. doi: 10.1007/978-981-32-9755-5_12.

PMID：31820391

A pipeline for ctDNA detection following primary tumor profiling using a cancer-related gene sequencing panel

Nishizuka SS, Sato KA, Hachiya T.

Methods Mol Biol. 2019;1908:229-241. doi: 10.1007/978-1-4939-9004-7_16.

PMID：30649732

Helicobacter pylori infection is associated with favorable outcome in advanced gastric cancer patients treated with S-1 adjuvant chemotherapy

Nishizuka SS, Tamura G, Nakatochi M, Fukushima N, Ohmori Y, Sumida C, Iwaya T, Takahashi T, Koeda K; Northern Japan Gastric Cancer Study Consortium.

J Surg Oncol. 2018 Apr;117(5):947-956. doi: 10.1002/jso.24977. Epub 2018 Jan 22.

PMID：29355977

Liver regeneration supported by Muse cells

Nishizuka SS, Suzuki Y, Katagiri H, Takikawa Y.

Adv Exp Med Biol. 2018;1103:219-241. doi: 10.1007/978-4-431-56847-6_12.

PMID：30484232

Colony lysate arrays for proteomic profiling of drug-tolerant persisters of cancer cell

Kume K and Nishizuka SS.

Anal Chem. 2017 Sep 5;89(17):8626-8631. doi: 10.1021/acs.analchem.7b01215. Epub 2017 Aug 11.

PMID：28753272

Inhibition of PI3K suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil

Ishida K, Ito C, Ohmori Y, Kume K, Sato KA, Koizumi Y, Konta A, Iwaya T, Nukatsuka M, Kobunai T, Takechi T, Nishizuka SS.

Sci Rep. 2017 May 23;7(1):2262. doi: 10.1038/s41598-017-02548-9.

PMID：28536445

Analysis of PIK3CA mutations and PI3K pathway proteins in advanced gastric cancer

Ito C, Nishizuka SS, Ishida K, Uesugi N, Sugai T, Tamura G, Koeda K, Sasaki A.

J Surg Res. 2017 May 15;212:195-204. doi: 10.1016/j.jss.2017.01.018. Epub 2017 Jan 30.

PMID：28550907

Ductular reactions in the liver regeneration process with local inflammation after physical partial hepatectomy

Suzuki Y, Katagiri H, Wang T, Kakisaka K, Kume K, Nishizuka SS, Takikawa Y.

Lab Invest. 2016 Nov;96(11):1211-1222. doi: 10.1038/labinvest.2016.97. Epub 2016 Sep 12.

PMID：27617400

Importance of metabolic rate to the relationship between the number of genes in a functional category and body size in Peto’s paradox for cancer

Takemoto K, Ii M, Nishizuka SS.

R Soc Open Sci. 2016 Sep 7;3(9):160267. doi: 10.1098/rsos.160267. eCollection 2016 Sep.

PMID：27703689

α-Amanitin restrains cancer relapse from drug-tolerant cell subpopulations via TAF15

Kume K, Ikeda M, Miura S, Ito K, Sato KA, Ohmori Y, Endo F, Katagiri H, Ishida K, Ito C, Iwaya T, Nishizuka SS.

Sci Rep. 2016 May 16;6:25895. doi: 10.1038/srep25895.

PMID：27181033

New era of integrated cancer biomarker discovery using reverse-phase protein arrays

Nishizuka SS and Mills GB.

Drug Metab Pharmacokinet. 2016 Feb;31(1):35-45. doi: 10.1016/j.dmpk.2015.11.009. Epub 2015 Dec 17.

PMID：26822993

A distinct subpopulation of bone marrow mesenchymal stem cells, Muse cells, directly commit to the replacement of liver components

Katagiri H, Kushida Y, Nojima M, Kuroda Y, Wakao S, Ishida K, Endo F, Kume K, Takahara T, Nitta H, Tsuda H, Dezawa M, Nishizuka SS.

Am J Transplant. 2016 Feb;16(2):468-83. doi: 10.1111/ajt.13537. Epub 2015 Dec 11.

PMID：26663569

Individualized mutation detection in circulating tumor DNA for monitoring colorectal tumor burden using a cancer-associated gene sequencing panel

Sato KA, Hachiya T, Iwaya T, Kume K, Matsuo T, Kawasaki K, Abiko Y, Akasaka R, Matsumoto T, Otsuka K, Nishizuka SS.

PLoS One. 2016 Jan 4;11(1):e0146275. doi: 10.1371/journal.pone.0146275. eCollection 2016.

PMID：26727500

Systematic protein level regulation via degradation machinery induced by genotoxic drugs

Kume K, Ishida K, Ikeda M, Takemoto K, Shimura T, Young L, Nishizuka SS.

J Proteome Res. 2016 Jan 4;15(1):205-15. doi: 10.1021/acs.jproteome.5b00759. Epub 2015 Dec 14.

PMID：26625007

Realizing the promise of reverse phase protein arrays for clinical, translational, and basic research: a workshop report: the RPPA (Reverse Phase Protein Array) society

Akbani R, Becker KF, Carragher N, Goldstein T, de Koning L, Korf U, Liotta L, Mills GB, Nishizuka SS, Pawlak M, Petricoin EF 3rd, Pollard HB, Serrels B, Zhu J.

Mol Cell Proteomics. 2014 Jul;13(7):1625-43. doi: 10.1074/mcp.O113.034918. Epub 2014 Apr 28.

PMID：24777629

A compensatory role of NF-κB to p53 in response to 5-FU-based chemotherapy for gastric cancer cell lines

Endo F, Nishizuka SS, Kume K, Ishida K, Katagiri H, Ishida K, Sato K, Iwaya T, Koeda K, Wakabayashi G.

PLoS One. 2014 Feb 27;9(2):e90155. doi: 10.1371/journal.pone.0090155. eCollection 2014.

PMID：24587255

Evaluation of chemosensitivity prediction using quantitative dose-response curve classification for highly advanced/relapsed gastric cancer

Matsuo T, Nishizuka SS, Ishida K, Endo F, Katagiri H, Kume K, Ikeda M, Koeda K, Wakabayashi G.

World J Surg Oncol. 2013 Jan 22;11:11. doi: 10.1186/1477-7819-11-11.

PMID：23339659

Molecular marker identification for relapse prediction in 5-FU-based adjuvant chemotherapy in gastric and colorectal cancers

shida K, Nishizuka SS, Chiba T, Ikeda M, Kume K, Endo F, Katagiri H, Matsuo T, Noda H, Iwaya T, Yamada N, Fujiwara H, Takahashi M, Itabashi T, Uesugi N, Maesawa C, Tamura G, Sugai T, Otsuka K, Koeda K, Wakabayashi G.

PLoS One. 2012;7(8):e43236. doi: 10.1371/journal.pone.0043236. Epub 2012 Aug 14.

PMID：22905237

Analysis of the anti-tumor effect of cetuximab using protein kinetics and mouse xenograft models

Matsuo T, Nishizuka SS, Ishida K, Iwaya T, Ikeda M, Wakabayashi G.

BMC Res Notes. 2011 May 10;4:140. doi: 10.1186/1756-0500-4-140.

PMID：21554739

Reverse-phase protein lysate microarray (RPA) for the experimental validation of quantitative protein network models

Nishizuka SS

Methods Mol Biol. 2011;785:65-77. doi: 10.1007/978-1-61779-286-1_6.

PMID：21901594