Patent

Japanese Patent No. 6632118

A pharmaceutical composition for inhibiting the relapse of the tumor

Registration date 2019.12.20
Patentee Iwate Medical University
Inventor Kohei, Kume / Nishizuka, Satoshi
Summary A toxin called α-Amanitin from the “death cap” (Amanita phalloides) suppresses peritonitis carcinomatosa, the status of cancer cell dissemination into the abdominal cavity. The toxin is lethal when ingested but the toxicity is minimized when co-administered with cisplatin, an anticancer agent.

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Japanese Patent No. 6621623 (P6621623)

The expression profile of the cell population

Registration date 2019.11.29
Patentee Iwate Medical University
Inventor Kume, Kohei / Nishizuka, Satoshi
Summary The invention relates to a method for molecular profiling of small number of cell subpopulations of cancer cells that survive under presence of anticancer drugs.

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Japanese Patent No. 6607634 (P6607634)

The TAF gene and its products as target molecules for inhibiting the recurrence of tumors

Registration date 2019.11.1
Patentee Iwate Medical University
Inventor Kume, Kohei / Nishizuka, Satoshi
Summary A advanced cancer disease status, namely peritonitis carcinomatosa, is often resistant to various treatments. The invention relates to TAF15 gene and its product as a therapeutic target.

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Japanese Patent No. 6544783 (P6544783)

The probe / primer library for the diagnosis of cancers

Registration date 2019.6.28
Patentee Iwate Medical University
Inventor Nishizuka, Satoshi / Iwaya, Takeshi
Out-licensed
Summary A set of targeted nucleic acid reagents for highly sensitive detection of circulating tumor DNA as a tumor marker. The invention relates to variety of diagnosis including post-treatment earlier relapse prediction, quantitative therapeutic efficacy evaluation, and confirmation of non-relapse status.

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Japanese Patent No. 2017080566 (Application Number)

Gastric cancer animal model (tentative)

Registration date 2017.4.14
Patentee Iwate Medical University
Inventor Nishizuka, Satoshi / Ishida, Kaoru
Summary A method for producing mouse gastric cancer model using 5-FU resistant gastric cancer cell line, MKN45/5FU. By injecting the MKN45/5FU cell line into submucosal layer of the stomach by liquid separation principle. A xenograft model for the same organ as well as the same layer of the tissue. Useful for validation in cancer metastasis and drug delivery studies.

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Japanese Patent No.5301234

Large scale collection method of protein samples

Registration date 2013.6.28
Patentee Iwate Medical University
Inventor Kume, Kohei / Nishizuka, Satoshi
Summary Quantitative monitoring of cellular network protein level in response to anticancer drugs requires a sufficient number of time-course cell lysates. This invention relates to a large-scale cell lysate collection from >1,000 time-point cell lysates.

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